Who Pix up Rac1?

Who Pix up Rac1?

1 0. 10 83/j cb.17 25 it i1 j cb 1725 it i1 Nicole LeBrasse [email protected] for the cofilin course O n page 671 , Chen and Macara unveil a mechanism by which Par-3 orchestrates cell polarization by regulating actin reorganization. Par-3 is one member of an apical polarity-inducing complex that also includes Par-6 and aPKC. The Par...

Targeting and activation of Rac1 are mediated by the exchange factor β-Pix

Rho guanosine triphosphatases (GTPases) are critical regulators of cytoskeletal dynamics and control complex functions such as cell adhesion, spreading, migration, and cell division. It is generally accepted that localized GTPase activation is required for the proper initiation of downstream signaling events, although the molecular mechanisms that control targeting of Rho GTPases are unknown. I...

Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2.

The nucleotide-binding domain and leucine-rich repeat containing protein NOD2 serves as a cytoplasmic pattern recognition molecule sensing bacterial muramyl dipeptide (MDP), whereas TLR2 mediates cell surface recognition of bacterial lipopeptides. In this study, we show that NOD2 stimulation activated Rac1 in human THP-1 cells and primary human monocytes. Rac1 inhibition or knock-down, or actin...

Which is which and who is who: Roger Waters up against Media

Pink Floyd was a British band whose work began in the late 60s. Roger Waters, the main contributor of the band, wrote almost all the lyrics and was also a main figure behind producing the motion picture of the album. He deliberately attacks Western media in both the lyrics he has written for the band and his solo projects. The present study finds this tendency of assaulting the media deeply roo...

Sequential Activation of Phosphatidylinositol 3-Kinase, Pix, Rac1, and Nox1 in Growth Factor-Induced Production of H2O2